@article{reinforcementlearningwithllmguidedaction, title = {Reinforcement Learning with LLM-Guided Action Spaces for Synthesizable Lead Optimization}, author = {Tao Li and Kaiyuan Hou and Tuan Vinh and Monika Raj and Zhichun Guo and Carl Yang}, year = {2026}, eprint = {2604.07669}, archivePrefix = {arXiv}, url = {https://arxiv.org/abs/2604.07669}, }