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A Deep Learning approach for Depressive Symptoms assessment in Parkinson's disease patients using facial videos

2025-05-05 · Ioannis Kyprakis, Vasileios Skaramagkas, Iro Boura, Georgios Karamanis, Dimitrios I. Fotiadis, Zinovia Kefalopoulou, Cleanthe Spanaki, Manolis Tsiknakis

Parkinson's disease (PD) is a neurodegenerative disorder, manifesting with motor and non-motor symptoms. Depressive symptoms are prevalent in PD, affecting up to 45% of patients. They are often underdiagnosed due to overlapping motor features, such as hypomimia. This study explores deep learning (DL) models-ViViT, Video Swin Tiny, and 3D CNN-LSTM with attention layers-to assess the presence and severity of depressive symptoms, as detected by the Geriatric Depression Scale (GDS), in PD patients through facial video analysis. The same parameters were assessed in a secondary analysis taking into account whether patients were one hour after (ON-medication state) or 12 hours without (OFF-medication state) dopaminergic medication. Using a dataset of 1,875 videos from 178 patients, the Video Swin Tiny model achieved the highest performance, with up to 94% accuracy and 93.7% F1-score in binary classification (presence of absence of depressive symptoms), and 87.1% accuracy with an 85.4% F1-score in multiclass tasks (absence or mild or severe depressive symptoms).

📄 PDF Abstract BibTeX arXiv:2505.03845

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Binary Classification

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Softmax The Softmax output function transforms a previous layer's output into a vector of probabilities. It is commonly used for multiclass classification. Given an input vector $x$…
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