A high-efficiency model indicating the role of inhibition in the resilience of neuronal networks to damage resulting from traumatic injury
Recent investigations of traumatic brain injuries have shown that these injuries can result in conformational changes at the level of individual neurons in the cerebral cortex. Focal axonal swelling is one consequence of such injuries and leads to a variable width along the cell axon. Simulations of the electrical properties of axons impacted in such a way show that this damage may have a nonlinear deleterious effect on spike-encoded signal transmission. The computational cost of these simulations complicates the investigation of the effects of such damage at a network level. We have developed an efficient algorithm that faithfully reproduces the spike train filtering properties seen in physical simulations. We use this algorithm to explore the impact of focal axonal swelling on small networks of integrate and fire neurons. We explore also the effects of architecture modifications to networks impacted in this manner. In all tested networks, our results indicate that the addition of presynaptic inhibitory neurons either increases or leaves unchanged the fidelity of the network's processing properties with respect to this damage.
Code (0)
등록된 구현이 없습니다.
Tasks
Physical SimulationsSimilar Papers 제목 키워드 기반
Different roles for inhibition in the rhythm-generating respiratory network
Unraveling the interplay of excitation and inhibition within rhythm-generating networks remains a fundamental issue in neuroscience. We use a biophysical model to investigate the different roles of local and long-range i…
RhythmUnderstanding the Transit Gap: A Comparative Study of On-Demand Bus Services and Urban Climate Resilience in South End, Charlotte, NC and Avondale, Chattanooga, TN
Urban design significantly impacts sustainability, particularly in the context of public transit efficiency and carbon emissions reduction. This study explores two neighborhoods with distinct urban designs: South End, Ch…
Inhibition in Random Neuronal Networks Enhances Response Variability and Disrupts Stimulus Discrimination
Inhibition is considered to shape neural activity, and broaden its pattern repertoire. In the sensory organs, where the anatomy of neural circuits is highly structured, lateral inhibition sharpens contrast among stimulus…
AnatomyBlockingEmergence of robust looming selectivity via coordinated inhibitory neural computations
In the locust's lobula giant movement detector neural pathways, four categories of inhibition, i.e., global inhibition, self-inhibition, lateral inhibition, and feed-forward inhibition, have been functionally explored in…
A Reconfigurable Mixed-signal Implementation of a Neuromorphic ADC
We present a neuromorphic Analogue-to-Digital Converter (ADC), which uses integrate-and-fire (I&F) neurons as the encoders of the analogue signal, with modulated inhibitions to decohere the neuronal spikes trains. The ar…
Decoder