A quantitative theory of viral-immune coevolution is within reach
Pathogens drive changes in host immune systems that in turn exert pressure for pathogens to evolve. Quantifying and understanding this constant coevolutionary process has clear practical global health implications. Yet its relatively easier accessibility compared to macroevolution makes it a fascinating system to learn about the basic laws of evolution. Focusing on immune-viral evolution, we present an overview of theoretical and experimental approaches that have recently started coming together to build the foundations for a quantitative and predictive co-evolutionary theory.
Code (0)
등록된 구현이 없습니다.
Similar Papers 제목 키워드 기반
Host-pathogen coevolution and the emergence of broadly neutralizing antibodies in chronic infections
The vertebrate adaptive immune system provides a flexible and diverse set of molecules to neutralize pathogens. Yet, viruses such as HIV can cause chronic infections by evolving as quickly as the adaptive immune system, …
Multiple possible patterns can emerge from virus-immune coevolution
The adaptive immune system engages in an arms race with evolving viruses, trying to generate new responses to viral strains that continually move away from the set of variants that have already elicited a functional immu…
Antigenic waves of virus-immune co-evolution
The evolution of many microbes and pathogens, including circulating viruses such as seasonal influenza, is driven by immune pressure from the host population. In turn, the immune systems of infected populations get updat…
Antigenic cooperation in Viral Populations: Transformation of Functions of Intra-Host Viral Variants
In this paper we study intra-host viral adaptation by antigenic cooperation - a mechanism of immune escape that serves as an alternative to the standard mechanism of escape by continuous genomic diversification and allow…
Virus-immune dynamics determined by prey-predator interaction network and epistasis in viral fitness landscape
Population dynamics and evolutionary genetics underly the structure of ecosystems, changing on the same timescale for interacting species with rapid turnover, such as virus (e.g. HIV) and immune response. Thus, an import…