Analysis of Neural Activation in Time-dependent Membrane Capacitance Models
Most models of neurons incorporate a capacitor to account for the marked capacitive behavior exhibited by the cell membrane. However, such capacitance is widely considered constant, thereby neglecting the possible effects of time-dependent membrane capacitance on neural excitability. This study presents a modified formulation of a neuron model with time-dependent membrane capacitance and shows that action potentials can be elicited for certain capacitance dynamics. Our main results can be summarized as: (a) it is necessary to have significant and abrupt variations in the capacitance to generate action potentials; (b) certain simple and explicitly constructed capacitance profiles with strong variations do generate action potentials; (c) forcing abrupt changes in the capacitance too frequently may result in no action potentials. These findings can have great implications for the design of ultrasound-based or other neuromodulation strategies acting through transiently altering the membrane capacitance of neurons.
Code (1)
Similar Papers 제목 키워드 기반
State dependent effects on the frequency response of prestin real and imaginary components of nonlinear capacitance
The outer hair cell (OHC) membrane harbors a voltage-dependent protein, prestin (SLC26a5), in high density, whose charge movement is evidenced as a nonlinear capacitance (NLC). NLC is bell-shaped, with its peak occurring…
On a nonlinear electromechanical model of nerve
The generation of action potential brings into play specific mechanosensory stimuli manifest in the variation of membrane capacitance, resulting from the selective membrane permeability to ions exchanges and testifying t…
modelDataset of Standard Tests of Nafion 112 Membrane and Membrane Electrode Assembly (MEA) Activation Tests of Proton Exchange Membrane (PEM) Fuel Cell
Reported data in this paper are about Nafion 112 membrane standard tests and MEA activation tests of PEM fuel cell in various operation condition. Dataset include two general electrochemical analysis method, Polarization…
The role of ion channels in the transmission of signals along axons
This work proposes a two-dimensional electrophysiological model for describing neuronal responses to external electric stimuli under patch-clamped conditions. Our proposed model successfully captures the key features of …
InformativenessModelling and simulation of electrical propagation in transmural slabs of scarred left ventricle tissue
We report three-dimensional and time-dependent numerical simulations of the propagation of electrical action potentials in a model of rabbit ventricular tissue. The simulations are performed using a finite-element method…