Beyond Barker: Infant Mortality at Birth and Ischaemic Heart Disease in Older Age
Adverse conditions in early life can have consequential impacts on individuals' health in older age. In one of the first papers on this topic, Barker and Osmond 1986 show a strong positive relationship between infant mortality rates in the 1920s and ischaemic heart disease in the 1970s. We go 'beyond Barker', first by showing that this relationship is robust to the inclusion of local geographic area fixed effects, but not family fixed effects. Second, we explore whether the average effects conceal underlying heterogeneity: we examine if the infant mortality effect offsets or reinforces one's genetic predisposition for heart disease. We find considerable heterogeneity that is robust to within-area as well as within-family analyses. Our findings show that the effects of one's early life environments mainly affect individuals with the highest genetic risk for developing heart disease. Put differently, in areas with the lowest infant mortality rates, the effect of one's genetic predisposition effectively vanishes. These findings suggest that advantageous environments can cushion one's genetic risk of developing heart disease.
Code (0)
등록된 구현이 없습니다.
Similar Papers 제목 키워드 기반
Infant Mortality Prediction using Birth Certificate Data
The Infant Mortality Rate (IMR) is the number of infants per 1000 that do not survive until their first birthday. It is an important metric providing information about infant health but it also measures the society's gen…
EpidemiologyGeneral ClassificationMortality PredictionPredictionDeciphering infant mortality. Part 1: empirical evidence
This paper is not (or at least not only) about human infant mortality. In line with reliability theory, "infant" will refer here to the time interval following birth during which the mortality (or failure) rate decreases…
Maternal education and offspring birthweight for gestational age: the mediating effect of smoking during pregnancy
Background Small for gestational age (SGA) birthweight, a risk factor of infant mortality and delayed child development, is associated with maternal educational attainment. Maternal tobacco smoking during pregnancy could…
Preterm Birth Prediction: Deriving Stable and Interpretable Rules from High Dimensional Data
Preterm births occur at an alarming rate of 10-15%. Preemies have a higher risk of infant mortality, developmental retardation and long-term disabilities. Predicting preterm birth is difficult, even for the most experien…
PredictionSensitivitySpecificityPredicting Extubation Readiness in Extreme Preterm Infants based on Patterns of Breathing
Extremely preterm infants commonly require intubation and invasive mechanical ventilation after birth. While the duration of mechanical ventilation should be minimized in order to avoid complications, extubation failure …
Time SeriesTime Series Analysis