Collaborative Attention and Consistent-Guided Fusion of MRI and PET for Alzheimer's Disease Diagnosis
Alzheimer's disease (AD) is the most prevalent form of dementia, and its early diagnosis is essential for slowing disease progression. Recent studies on multimodal neuroimaging fusion using MRI and PET have achieved promising results by integrating multi-scale complementary features. However, most existing approaches primarily emphasize cross-modal complementarity while overlooking the diagnostic importance of modality-specific features. In addition, the inherent distributional differences between modalities often lead to biased and noisy representations, degrading classification performance. To address these challenges, we propose a Collaborative Attention and Consistent-Guided Fusion framework for MRI and PET based AD diagnosis. The proposed model introduces a learnable parameter representation (LPR) block to compensate for missing modality information, followed by a shared encoder and modality-independent encoders to preserve both shared and specific representations. Furthermore, a consistency-guided mechanism is employed to explicitly align the latent distributions across modalities. Experimental results on the ADNI dataset demonstrate that our method achieves superior diagnostic performance compared with existing fusion strategies.
Code (0)
등록된 구현이 없습니다.
Similar Papers 제목 키워드 기반
DiGAN: Diffusion-Guided Attention Network for Early Alzheimer's Disease Detection
Early diagnosis of Alzheimer's disease (AD) remains a major challenge due to the subtle and temporally irregular progression of structural brain changes in the prodromal stages. Existing deep learning approaches require …
Alzheimer's Disease DetectionAD-Reasoning: Multimodal Guideline-Guided Reasoning for Alzheimer's Disease Diagnosis
Alzheimer's disease (AD) diagnosis requires integrating neuroimaging with heterogeneous clinical evidence and reasoning under established criteria, yet most multimodal models remain opaque and weakly guideline-aligned. W…
A Prior Guided Adversarial Representation Learning and Hypergraph Perceptual Network for Predicting Abnormal Connections of Alzheimer's Disease
Alzheimer's disease is characterized by alterations of the brain's structural and functional connectivity during its progressive degenerative processes. Existing auxiliary diagnostic methods have accomplished the classif…
DiagnosticFunctional ConnectivityRepresentation LearningAn Interpretable Multi-Plane Fusion Framework With Kolmogorov-Arnold Network Guided Attention Enhancement for Alzheimer's Disease Diagnosis
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that severely impairs cognitive function and quality of life. Timely intervention in AD relies heavily on early and precise diagnosis, which remains ch…
Multi-Modal Graph Neural Network with Transformer-Guided Adaptive Diffusion for Preclinical Alzheimer Classification
The graphical representation of the brain offers critical insights into diagnosing and prognosing neurodegenerative disease via relationships between regions of interest (ROIs). Despite recent emergence of various Graph …
Graph Neural Network