Complex Networks and the Drug Repositioning Problem
In this Master's thesis, the graph properties of a multi-level drug-protein network are studied, as well as how the network's shape has informed discoveries over the years, identifying primarily crawling discoveries and a smaller number of hopping discoveries. Finally, the network structure is used to inform a network diffusion recommendation system and to prioritize existing drugs for repurposing against proteins in organisms that cause Neglected Tropical Diseases.
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