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Unified Framework for Histopathology Image Augmentation and Classification via Generative Models

2022-12-20 · Meng Li, Chaoyi Li, Can Peng, Brian C. Lovell

Deep learning techniques have become widely utilized in histopathology image classification due to their superior performance. However, this success heavily relies on the availability of substantial labeled data, which necessitates extensive and costly manual annotation by domain experts. To address this challenge, researchers have recently employed generative models to synthesize data for augmentation, thereby enhancing classification model performance. Traditionally, this involves generating synthetic data first and then training the classification model with both synthetic and real data, which creates a two-stage, time-consuming workflow. To overcome this limitation, we propose an innovative unified framework that integrates the data generation and model training stages into a unified process. Our approach utilizes a pure Vision Transformer (ViT)-based conditional Generative Adversarial Network (cGAN) model to simultaneously handle both image synthesis and classification. An additional classification head is incorporated into the cGAN model to enable simultaneous classification of histopathology images. To improve training stability and enhance the quality of generated data, we introduce a conditional class projection technique that helps maintain class separation during the generation process. We also employ a dynamic multi-loss weighting mechanism to effectively balance the losses of the classification tasks. Furthermore, our selective augmentation mechanism actively selects the most suitable generated images for data augmentation to further improve performance. Extensive experiments on histopathology datasets show that our unified synthetic augmentation framework consistently enhances the performance of histopathology image classification models.

📄 PDF Abstract BibTeX arXiv:2212.09977

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Tasks

ClassificationData AugmentationGenerative Adversarial NetworkImage Augmentationimage-classificationImage ClassificationImage GenerationMedical Image Analysis

Methods 이 논문이 사용한 방법론

Multi-Head Attention 설명 없음
Attention 설명 없음
Linear Layer A Linear Layer is a projection $\mathbf{XW + b}$.
Layer Normalization Unlike batch normalization, Layer Normalization directly estimates the normalization statistics from the summed inputs…
Softmax The Softmax output function transforms a previous layer's output into a vector of probabilities. It is commonly used for multiclass classification. Given an input vector $x$…
Dense Connections Dense Connections, or Fully Connected Connections, are a type of layer in a deep neural network that use a linear operation where every input is connected to every output…
Residual Connection 설명 없음
Vision Transformer The Vision Transformer, or ViT, is a model for image classification that employs a Transformer-like architecture over…

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