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CT-based COVID-19 Triage: Deep Multitask Learning Improves Joint Identification and Severity Quantification

2020-06-02 · Mikhail Goncharov, Maxim Pisov, Alexey Shevtsov, Boris Shirokikh, Anvar Kurmukov, Ivan Blokhin, Valeria Chernina, Alexander Solovev, Victor Gombolevskiy, Sergey Morozov, Mikhail Belyaev

The current COVID-19 pandemic overloads healthcare systems, including radiology departments. Though several deep learning approaches were developed to assist in CT analysis, nobody considered study triage directly as a computer science problem. We describe two basic setups: Identification of COVID-19 to prioritize studies of potentially infected patients to isolate them as early as possible; Severity quantification to highlight studies of severe patients and direct them to a hospital or provide emergency medical care. We formalize these tasks as binary classification and estimation of affected lung percentage. Though similar problems were well-studied separately, we show that existing methods provide reasonable quality only for one of these setups. We employ a multitask approach to consolidate both triage approaches and propose a convolutional neural network to combine all available labels within a single model. In contrast with the most popular multitask approaches, we add classification layers to the most spatially detailed upper part of U-Net instead of the bottom, less detailed latent representation. We train our model on approximately 2000 publicly available CT studies and test it with a carefully designed set consisting of 32 COVID-19 studies, 30 cases with bacterial pneumonia, 31 healthy patients, and 30 patients with other lung pathologies to emulate a typical patient flow in an out-patient hospital. The proposed multitask model outperforms the latent-based one and achieves ROC AUC scores ranging from 0.87+-01 (bacterial pneumonia) to 0.97+-01 (healthy controls) for Identification of COVID-19 and 0.97+-01 Spearman Correlation for Severity quantification. We release all the code and create a public leaderboard, where other community members can test their models on our test dataset.

📄 PDF Abstract BibTeX arXiv:2006.01441

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Binary Classification

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Concatenated Skip Connection A Concatenated Skip Connection is a type of skip connection that seeks to reuse features by concatenating them to new layers, allowing more information to be retained from…
Convolution A convolution is a type of matrix operation, consisting of a kernel, a small matrix of weights, that slides over input data performing element-wise multiplication with the…
Max Pooling Max Pooling is a pooling operation that calculates the maximum value for patches of a feature map, and uses it to create a downsampled (pooled) feature map. It is usually…
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