Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites
Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.
Code (0)
등록된 구현이 없습니다.
Similar Papers 제목 키워드 기반
Stochastic fluctuations promote ordered pattern formation of cells in the Notch-Delta signaling pathway
The Notch-Delta signaling pathway mediates cell differentiation implicated in many regulatory processes including spatiotemporal patterning in tissues by promoting alternate cell fates between neighboring cells. At the m…
Dynamics of cell-type transition mediated by epigenetic modifications
Maintaining tissue homeostasis requires appropriate regulation of stem cell differentiation. The Waddington landscape posits that gene circuits in a cell form a potential landscape of different cell types, wherein cells …
Symbiotic Cell Differentiation and Cooperative Growth in Multicellular Aggregates
As cells grow and divide under a given environment, they become crowded and resources are limited, as seen in bacterial biofilms and multicellular aggregates. These cells often show strong interactions through exchanging…
Technical Report: Modelling Multiple Cell Types with Partial Differential Equations
Partial differential equations are a convenient way to describe reaction- advection-diffusion processes of signalling models. If only one cell type is present, and tissue dynamics can be neglected, the equations can be s…
Using Deep Learning to Predict Neural Stem Cell Differentiation in Regenerative Medicine
Over one in three people are affected by neurodegenerative disorders. Neural stem cells, which are multipotent regenerative cells with the potential to differentiate into any of the neural cell types, have immense therap…