Dominance and multi-locus interaction
Dominance is usually considered a constant value that describes the relative difference in fitness or phenotype between heterozygotes and the average of homozygotes at a focal polymorphic locus. However, the observed dominance can vary with the genetic background of the focal locus. Here, alleles at other loci modify the observed phenotype through position effects or dominance modifiers that are sometimes associated with pathogen resistance, lineage, sex, or mating type. Theoretical models have illustrated how variable dominance appears in the context of multi-locus interaction (epistasis). Here, we review empirical evidence for variable dominance and how the observed patterns may be captured by proposed epistatic models. We highlight how integrating epistasis and dominance is crucial for comprehensively understanding adaptation and speciation.
Code (0)
등록된 구현이 없습니다.
Tasks
PositionSimilar Papers 제목 키워드 기반
Two-locus clines on the real line with a step environment
The shape of allele-frequency clines maintained by migration-selection balance depends not only on the properties of migration and selection, but also on the dominance relations among alleles and on linkage to other loci…
Numerical IntegrationVocal Bursts Valence PredictionThe thermodynamics of protein aggregation reactions may underpin the enhanced metabolic efficiency associated with heterosis, some balancing selection, and the evolution of ploidy levels
Identifying the physical basis of heterosis (or hybrid vigor) has remained elusive despite over a hundred years of research on the subject. The three main theories of heterosis are dominance theory, overdominance theory,…
Gaze Perception in Humans and CNN-Based Model
Making accurate inferences about other individuals' locus of attention is essential for human social interactions and will be important for AI to effectively interact with humans. In this study, we compare how a CNN (con…
modelLong and short range multi-locus QTL interactions in a complex trait of yeast
We analyse interactions of Quantitative Trait Loci (QTL) in heat selected yeast by comparing them to an unselected pool of random individuals. Here we re-examine data on individual F12 progeny selected for heat tolerance…
An Effective Hydrodynamic Description of Marching Locusts
A fundamental question in complex systems is how to relate interactions between individual components ("microscopic description") to the global properties of the system ("macroscopic description"). Another fundamental qu…