Engineered Zwitterion-Infused Clay Composites with Antibacterial and Antifungal Efficacy
Microbes and pathogens play a detrimental role in healing wounds, causing infections like impetigo through bodily fluids and skin and entering the bloodstream through the wounds, thereby hindering the healing process and tissue regeneration. Clay, known for its long history of natural therapeutic use, has emerged as one of the most promising candidates for biomedical applications due to its non-toxic nature, porosity, high surface area, ubiquity, and excellent cation exchange capacity. This study demonstrates an innovative approach to engineering an organo-functionalized, infection-resistant, easy-to-use bandage material from clay, an environmentally benign and sustainable material. The hybrid membranes have been developed using clays, zwitterions, silver ions, and terbinafine hydrochloride (TBH) to impart antibacterial and antifungal efficacy. A critical aspect of this study is embedding organic molecules and metal ions with the clays and releasing them to resist the growth and kill the pathogens. The antimicrobial efficacy of the membranes has been tested using a zone of inhibition study against the most common microbes in skin wounds, viz. S. aureus, E. coli, and C. albicans. Results from our studies not only demonstrate the potential of these hybrid clay membranes as a cost-effective, scalable, and effective solution for treating microbial infections but also instill newer avenues for point-of-care wound-healing treatments, offering hope for improved patient outcomes.
Code (0)
등록된 구현이 없습니다.
Similar Papers 제목 키워드 기반
Prevention of bacterial adhesion to zwitterionic biocompatible mesoporous glasses
Novel materials, based on Mesoporous Bioactive Glasses (MBGs) in the ternary system SiO2-CaO-P2O5, decorated with (3-aminopropyl)triethoxysilane (APTES) and subsequently with amino acid Lysine (Lys), by post-grafting met…
A new promising material for biological applications: multi-level physical modification of AgNPs-decorated PEEK
In the case of polymer medical devices, the surface design plays a crucial role in contact with human tissue. The use of AgNPs as antibacterial agents is well known; however, their anchoring into the polymer surface can …
Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with lowfouling and reduced cell uptake properties
The design of drug delivery systems needs to consider biocompatibility and host body recognition for an adequate actuation. In this work, mesoporous silica nanoparticles (MSNs) surfaces were successfully modified with tw…
Mesoporous core-shell silica nanoparticles with anti-fouling properties for ovarian cancer therapy
Mesoporous silica nanoparticles (MSNPs) have many potential applications in biomedical fields. However, when MSNPs are exposed to plasma, protein adsorption leads to opsonization and decreases blood circulation time. A n…
Strontium-releasing mesoporous bioactive glasses with anti-adhesive zwitterionic surface as advanced biomaterials for bone tissue regeneration
Hypothesis The treatment of bone fractures still represents a challenging clinical issue when complications due to impaired bone remodelling (i.e. osteoporosis) or infections occur. These clinical needs still require a r…