Key challenges facing data-driven multicellular systems biology
Increasingly sophisticated experiments, coupled with large-scale computational models, have the potential to systematically test biological hypotheses to drive our understanding of multicellular systems. In this short review, we explore key challenges that must be overcome to achieve robust, repeatable data-driven multicellular systems biology. If these challenges can be solved, we can grow beyond the current state of isolated tools and datasets to a community-driven ecosystem of interoperable data, software utilities, and computational modeling platforms. Progress is within our grasp, but it will take community (and financial) commitment.
Code (0)
등록된 구현이 없습니다.
Similar Papers 제목 키워드 기반
TI$^2$PS: A Topology-Informed Inverse Design Framework for Stochastic Multicellular Pattern Formation
This study proposes a novel framework to estimate parameters for reproducing target multicellular patterns using an agent-based model (ABM). Two major challenges in multicellular ABMs are estimating cell-level parameters…
Progress towards quantitative design principles of multicellular systems
Living systems, particularly multicellular systems, often seem hopelessly complex. But recent studies have suggested that beneath this complexity, there may be unifying quantitative principles that we are only now starti…
DiversityTopSpace: spatial topic modeling for unsupervised discovery of multicellular spatial tissue structures in multiplex imaging
Motivation: Understanding the spatial architecture of tissues is essential for decoding the complex interactions within cellular ecosystems and their implications for disease pathology and clinical outcomes. Recent advan…
ClusteringGaussian ProcessesUncertainty QuantificationChemotaxis-Driven Instabilities Govern Size, Shape and Migration Efficiency of Multicellular Clusters
The collective chemotaxis of multicellular clusters is an important phenomenon in various physiological contexts, ranging from embryonic development to cancer metastasis. Such clusters often display interesting shape dyn…
Multicellular self-organization in Escherichia coli
Escherichia coli has long been a trusty companion, maintaining health in our guts and advancing biological knowledge in the laboratory. In light of recent findings, we discuss multicellular self-organization in E. coli a…