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Knowledge Graph-Driven Expert-Level Reasoning for Neuroscience

Knowledge graph (KG) is an abstraction that can be extracted from text corpora and used for in-depth reasoning. Prior work has leveraged KGs to fine-tune language models (LMs), enabling domain-specific superintelligence. In this work, we explore whether KG-driven in-depth reasoning capabilities can emerge in neuroscience using only information contained within a single authoritative textbook. The central hypothesis is that structured knowledge, when distilled into a high-quality KG and converted into KG-grounded question-answer (QA) supervision, is sufficient to produce expert-level reasoning through a fine-tuned LM that surpasses large language models (LLMs) in accuracy, while employing orders of magnitude fewer parameters. We construct a textbook-derived KG via a dual-LLM validation pipeline, expand it with a masked LM trained on the KG topology, generate multi-hop QA items, which include QA pairs and reasoning traces, to fine-tune an LM exclusively on KG-derived supervision, and apply reinforcement learning using path-derived KG signals as implicit reward models. Our results demonstrate that deep, mechanistic neuroscience understanding can be induced in the model without reliance on large, heterogeneous web-scale corpora. The KG-based synthetic neuroscience curriculum that readers can quiz themselves on, and the fine-tuned LM, are available at the following GitHub location: https://kg-bottom-up-superintelligence.github.io/neuro-bench.

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