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Learning normal appearance for fetal anomaly screening: Application to the unsupervised detection of Hypoplastic Left Heart Syndrome

2020-11-15 · Elisa Chotzoglou, Thomas Day, Jeremy Tan, Jacqueline Matthew, David Lloyd, Reza Razavi, John Simpson, Bernhard Kainz

Congenital heart disease is considered as one the most common groups of congenital malformations which affects $6-11$ per $1000$ newborns. In this work, an automated framework for detection of cardiac anomalies during ultrasound screening is proposed and evaluated on the example of Hypoplastic Left Heart Syndrome (HLHS), a sub-category of congenital heart disease. We propose an unsupervised approach that learns healthy anatomy exclusively from clinically confirmed normal control patients. We evaluate a number of known anomaly detection frameworks together with a model architecture based on the $\alpha$-GAN network and find evidence that the proposed model performs significantly better than the state-of-the-art in image-based anomaly detection, yielding average $0.81$ AUC \emph{and} a better robustness towards initialisation compared to previous works.

📄 PDF Abstract BibTeX arXiv:2012.03679

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AnatomyAnomaly Detection

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