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Low-dimensional functionality of complex network dynamics: Neuro-sensory integration in the Caenorhabditis elegans connectome

2013-10-24 · James Kunert, Eli Shlizerman, J. Nathan Kutz

We develop a biophysical model of neuro-sensory integration in the model organism Caenorhabditis elegans. Building on recent experimental findings of the neuron conductances and their resolved connectome, we posit the first full dynamic model of the neural voltage excitations that allows for a characterization of input stimuli to behavioral responses. Thus a clear connection between receptory cell inputs to downstream motor-responses is illustrated, showing that robust, low-dimensional bifurcation structures dominate neural pathways of activity. The underlying bifurcation structures discovered, i.e. an induced Hopf bifurcation, are critical in explaining behavioral responses such as swimming and crawling. More broadly, we demonstrate that complex dynamical networks can produce robust functionality from underlying low-dimensional bifurcations.

📄 PDF Abstract BibTeX arXiv:1310.6689

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