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Microvasculature Segmentation and Inter-capillary Area Quantification of the Deep Vascular Complex using Transfer Learning

Purpose: Optical Coherence Tomography Angiography (OCT-A) permits visualization of the changes to the retinal circulation due to diabetic retinopathy (DR), a microvascular complication of diabetes. We demonstrate accurate segmentation of the vascular morphology for the superficial capillary plexus and deep vascular complex (SCP and DVC) using a convolutional neural network (CNN) for quantitative analysis. Methods: Retinal OCT-A with a 6x6mm field of view (FOV) were acquired using a Zeiss PlexElite. Multiple-volume acquisition and averaging enhanced the vessel network contrast used for training the CNN. We used transfer learning from a CNN trained on 76 images from smaller FOVs of the SCP acquired using different OCT systems. Quantitative analysis of perfusion was performed on the automated vessel segmentations in representative patients with DR. Results: The automated segmentations of the OCT-A images maintained the hierarchical branching and lobular morphologies of the SCP and DVC, respectively. The network segmented the SCP with an accuracy of 0.8599, and a Dice index of 0.8618. For the DVC, the accuracy was 0.7986, and the Dice index was 0.8139. The inter-rater comparisons for the SCP had an accuracy and Dice index of 0.8300 and 0.6700, respectively, and 0.6874 and 0.7416 for the DVC. Conclusions: Transfer learning reduces the amount of manually-annotated images required, while producing high quality automatic segmentations of the SCP and DVC. Using high quality training data preserves the characteristic appearance of the capillary networks in each layer. Translational Relevance: Accurate retinal microvasculature segmentation with the CNN results in improved perfusion analysis in diabetic retinopathy.

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