Modeling the Effect of Blunt Impact on Mitochondrial Dysfunction in Cartilage
Mounting evidence for the role of oxidative stress in the degeneration of articular cartilage after an injurious impact requires our modeling & simulation efforts to temporarily shift from just describing the effect of mechanical stress and inflammation on osteoarthritis (OA). The hypothesis that the injurious impact causes irreversible damage to chondrocyte mitochondria, which in turn increase their production of free radicals, affecting their energy production and their ability to rebuild the extracellular matrix, has to be modeled and the processes quantified in order to further the understanding of OA, its causes, and viable treatment options. The current article presents a calibrated model that captures the damage oxidative stress incurs on the cell viability, ATP production, and cartilage stability in a cartilage explant after a drop-tower impact. The model validates the biological hypothesis and will be used in further efforts to identify possibilities for treatment and be a part of a bigger modeling & simulation framework for the development of OA.
Code (0)
등록된 구현이 없습니다.
Similar Papers 제목 키워드 기반
MEGADOCK-Web-Mito: human mitochondrial protein-protein interaction prediction database
Mitochondrial diseases are largely caused by dysfunction in mitochondrial proteins. However, annotations of human mitochondrial proteins are scattered across various public databases and individual studies. To facilitate…
PredictionModeling Bioelectric State Transitions in Glial Cells: An ASAL-Inspired Computational Approach to Glioblastoma Initiation
Understanding how glioblastoma (GBM) emerges from initially healthy glial tissue requires models that integrate bioelectrical, metabolic, and multicellular dynamics. This work introduces an ASAL-inspired agent-based fram…
Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight
A meta-analysis of spaceflight data from both mouse and human flights reveals a striking overlap with Parkinson's disease (PD). Parallels include: changes in gait, loss of dopamine, sustained changes in the basal ganglia…
The Transcription Factor E4F1 Coordinates CHK1-Dependent Checkpoint and Mitochondrial Functions
Recent data support the notion that a group of key transcriptional regulators involved in tumorigenesis, including MYC, p53, E2F1, and BMI1, share an intriguing capacity to simultaneously regulate metabolism and cell cyc…
Taenia Biomolecular Phylogeny and the Impact of Mitochondrial Genes on this Latter
Variations in mitochondrial genes are usually considered to infer phylogenies. However some of these genes are lesser constraint than other ones, and thus may blur the phylogenetic signals shared by the majority of the m…