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MolMole: Molecule Mining from Scientific Literature

2025-04-30 · LG AI Research, Sehyun Chun, Jiye Kim, Ahra Jo, Yeonsik Jo, Seungyul Oh, Seungjun Lee, Kwangrok Ryoo, Jongmin Lee, Seung Hwan Kim, Byung Jun Kang, Soonyoung Lee, Jun Ha Park, Chanwoo Moon, Jiwon Ham, Haein Lee, Heejae Han, Jaeseung Byun, Soojong Do, Minju Ha, Dongyun Kim, Kyunghoon Bae, Woohyung Lim, Edward Hwayoung Lee, Yongmin Park, Jeongsang Yu, Gerrard Jeongwon Jo, Yeonjung Hong, Kyungjae Yoo, Sehui Han, Jaewan Lee, ChangYoung Park, Kijeong Jeon, Sihyuk Yi

The extraction of molecular structures and reaction data from scientific documents is challenging due to their varied, unstructured chemical formats and complex document layouts. To address this, we introduce MolMole, a vision-based deep learning framework that unifies molecule detection, reaction diagram parsing, and optical chemical structure recognition (OCSR) into a single pipeline for automating the extraction of chemical data directly from page-level documents. Recognizing the lack of a standard page-level benchmark and evaluation metric, we also present a testset of 550 pages annotated with molecule bounding boxes, reaction labels, and MOLfiles, along with a novel evaluation metric. Experimental results demonstrate that MolMole outperforms existing toolkits on both our benchmark and public datasets. The benchmark testset will be publicly available, and the MolMole toolkit will be accessible soon through an interactive demo on the LG AI Research website. For commercial inquiries, please contact us at \href{mailto:contact_ddu@lgresearch.ai}{contact\_ddu@lgresearch.ai}.

📄 PDF Abstract BibTeX arXiv:2505.03777

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