Mosaic organization of DNA nucleotides
Long-range power-law correlations have been reported recently for DNA sequences containing noncoding regions. We address the question of whether such correlations may be a trivial consequence of the known mosaic structure (‘‘patchiness’’) of DNA. We analyze two classes of controls consisting of patchy nucleotide sequences generated by different algorithms—one without and one with long-range power-law correlations. Although both types of sequences are highly heterogeneous, they are quantitatively distinguishable by new fluctuation analysis method that differentiates local patchiness from long-range correlations. Application of this analysis to selected DNA sequences demonstrates that patchiness is not sufficient to account for long-range correlation properties.
Code (1)
Tasks
Time Series AnalysisMethods 이 논문이 사용한 방법론
Similar Papers 제목 키워드 기반
Feature extraction from complex networks: A case of study in genomic sequences classification
This work presents a new approach for classification of genomic sequences from measurements of complex networks and information theory. For this, it is considered the nucleotides, dinucleotides and trinucleotides of a ge…
ClassificationGeneral ClassificationThe Future of Decoding Non-Standard Nucleotides: Leveraging Nanopore Sequencing for Expanded Genetic Codes
Expanding genetic codes from natural standard nucleotides to artificial non-standard nucleotides marks a significant advancement in synthetic biology, with profound implications for biotechnology and medicine. Decoding t…
Bioconjugated oligonucleotides: recent developments and thera-eutic applications
Oligonucleotide-based agents have the potential to treat or cure almost any disease, and are one of the key therapeutic drug classes of the future. Bioconjugated oligonucleotides, a subset of this class, are emerging fro…
SpecificityA Review of Image Mosaicing Techniques
Image Mosaicing is a method of constructing multiple images of the same scene into a larger image. The output of the image mosaic will be the union of two input images. Image-mosaicing algorithms are used to get mosaiced…
Image RegistrationCorrelations between promoter activity and its nucleotide positions in spacing region
Transcription is one of the essential processes for cells to read genetic information encoded in genes, which is initiated by the binding of RNA polymerase to related promoter. Experiments have found that the nucleotide …