Multivariate brain-cognition associations in euthymic bipolar disorder
Background: People with bipolar disorder (BD) tend to show widespread cognitive impairment compared to healthy controls. Impairments in processing speed (PS), attention, and executive function (EF) may represent 'core' impairments that have a role in wider cognitive dysfunction. Cognitive impairments appear to relate to structural brain abnormalities in BD, but whether core deficits are related to particular brain regions is unclear and much of the research on brain-cognition associations is limited by univariate analysis and small samples. Methods: Euthymic BD patients (n=56) and matched healthy controls (n=26) underwent T1-weighted MRI scans and completed neuropsychological tests of PS, attention, and EF. We utilised public datasets to develop a normative model of cortical thickness (n=5,977) to generate robust estimations of cortical abnormalities in patients. Canonical correlation analysis was used to assess multivariate brain-cognition associations in BD, controlling for age, sex, and premorbid IQ. Results: BD showed impairments on tests of PS, attention, and EF, and abnormal cortical thickness in several brain regions compared to healthy controls. Impairments in tests of PS and EF were most strongly associated with cortical thickness in left inferior temporal, right entorhinal, and right temporal pole areas. Conclusion: Impairments in PS, attention, and EF can be observed in euthymic BD and may be related to abnormal cortical thickness in temporal regions. Future research should continue to leverage multivariate methods to examine complex brain-cognition associations in BD. Future research may benefit from exploring covariance between traditional brain structural morphological metrics such as cortical thickness, cortical volume, and surface area.
Code (0)
등록된 구현이 없습니다.
Methods 이 논문이 사용한 방법론
Similar Papers 제목 키워드 기반
Long-Short Ensemble Network for Bipolar Manic-Euthymic State Recognition Based on Wrist-worn Sensors
Manic episodes of bipolar disorder can lead to uncritical behaviour and delusional psychosis, often with destructive consequences for those affected and their surroundings. Early detection and intervention of a manic epi…
Violent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders)
Background: Bipolar disorder (BD) is a chronic, lifelong condition, associated with increased risk of obesity, cognitive impairment, and suicidal behaviors. Abdominal obesity and a higher risk of violent suicide attempt …
A hierarchical Bayesian model to find brain-behaviour associations in incomplete data sets
Canonical Correlation Analysis (CCA) and its regularised versions have been widely used in the neuroimaging community to uncover multivariate associations between two data modalities (e.g., brain imaging and behaviour). …
Bayesian InferenceMissing ValuesCovariate-guided Bayesian mixture model for multivariate time series
With rapid development of techniques to measure brain activity and structure, statistical methods for analyzing modern brain-imaging play an important role in the advancement of science. Imaging data that measure brain f…
Mixture-of-ExpertsTime SeriesTime Series AnalysisFinding the needle in high-dimensional haystack: A tutorial on canonical correlation analysis
Since the beginning of the 21st century, the size, breadth, and granularity of data in biology and medicine has grown rapidly. In the example of neuroscience, studies with thousands of subjects are becoming more common, …