Neural Frailty Machine: Beyond proportional hazard assumption in neural survival regressions
We present neural frailty machine (NFM), a powerful and flexible neural modeling framework for survival regressions. The NFM framework utilizes the classical idea of multiplicative frailty in survival analysis as a principled way of extending the proportional hazard assumption, at the same time being able to leverage the strong approximation power of neural architectures for handling nonlinear covariate dependence. Two concrete models are derived under the framework that extends neural proportional hazard models and nonparametric hazard regression models. Both models allow efficient training under the likelihood objective. Theoretically, for both proposed models, we establish statistical guarantees of neural function approximation with respect to nonparametric components via characterizing their rate of convergence. Empirically, we provide synthetic experiments that verify our theoretical statements. We also conduct experimental evaluations over $6$ benchmark datasets of different scales, showing that the proposed NFM models achieve predictive performance comparable to or sometimes surpassing state-of-the-art survival models. Our code is publicly availabel at https://github.com/Rorschach1989/nfm
Code (1)
Similar Papers 제목 키워드 기반
Bayesian Semiparametric Mixture Cure (Frailty) Models
In recent years, mixture cure models have gained increasing popularity in survival analysis as an alternative to the Cox proportional hazards model, particularly in settings where a subset of patients is considered cured…
A Multiple kernel testing procedure for non-proportional hazards in factorial designs
In this paper we propose a Multiple kernel testing procedure to infer survival data when several factors (e.g. different treatment groups, gender, medical history) and their interaction are of interest simultaneously. Ou…
Survival AnalysisBeyond Cox Models: Assessing the Performance of Machine-Learning Methods in Non-Proportional Hazards and Non-Linear Survival Analysis
Survival analysis often relies on Cox models, assuming both linearity and proportional hazards (PH). This study evaluates machine and deep learning methods that relax these constraints, comparing their performance with p…
Survival AnalysisSurvival PredictionSurvival Forests under Test: Impact of the Proportional Hazards Assumption on Prognostic and Predictive Forests for ALS Survival
We investigate the effect of the proportional hazards assumption on prognostic and predictive models of the survival time of patients suffering from amyotrophic lateral sclerosis (ALS). We theoretically compare the under…
ICODEN: Ordinary Differential Equation Neural Networks for Interval-Censored Data
Predicting time-to-event outcomes when event times are interval censored is challenging because the exact event time is unobserved. Many existing survival analysis approaches for interval-censored data rely on strong mod…