Noise-induced network bursts and coherence in a calcium-mediated neural network
Noise-induced population bursting has been widely identified to play important roles in the information process. We constructed a mathematical model for a random and sparse neural network where bursting can be induced from the resting state by the global stochastic stimulus. Importantly, the noise-induced bursting dynamics of this network are mediated by calcium conductance. We use two spectral measures to evaluate the network coherence in the context of network bursts, the spike trains of all neurons and the individual bursts of all neurons. Our results show that the coherence of the network is optimized by an optimal level of stochastic stimulus, which is known as coherence resonance (CR). We also demonstrate that the interplay of calcium conductance and noise intensity can modify the degree of CR.
Code (0)
등록된 구현이 없습니다.
Similar Papers 제목 키워드 기반
Mathematical model of subthalamic nucleus neuron: characteristic activity patterns and bifurcation analysis
The subthalamic nucleus (STN) has an important role in the pathophysiology of the basal ganglia in Parkinson's disease. The ability of STN cells to generate bursting rhythms under either transient or sustained hyperpolar…
RhythmG protein-coupled receptor-mediated calcium signaling in astrocytes
Astrocytes express a large variety of G~protein-coupled receptors (GPCRs) which mediate the transduction of extracellular signals into intracellular calcium responses. This transduction is provided by a complex network o…
Tonic activation of extrasynaptic NMDA receptors decreases intrinsic excitability and promotes bistability in a model of neuronal activity
NMDA receptors (NMDA-R) typically contribute to excitatory synaptic transmission in the central nervous system. While calcium influx through NMDA-R plays a critical role in synaptic plasticity, experimental evidence indi…
Deregulation of calcium homeostasis in Bcr-Abl-dependent chronic myeloid leukemia
Background: Chronic myeloid leukemia (CML) results from hematopoietic stem cell transformation by the bcr-abl chimeric oncogene, encoding a 210 kDa protein with constitutive tyrosine kinase activity. In spite of the effi…
An increase in membrane cholesterol by graphene oxide disrupts calcium homeostasis in primary astrocytes
The use of graphene nanomaterials (GNMs) for biomedical applications targeted to the central nervous system is exponentially increasing, although precise information on their effects on brain cells is lacking. In this wo…