Perspective: Speculative role of Tmp21 mediated protein secretory pathway during endoplasmic reticulum (ER) stress induced chronic inflammation
By deploying myelofibrosis as the disease context, I wish to propose that increased availability of Tmp21 (an NFAT gene target) induces aberrant protein secretion from the ER contributing to pathological consequences, which has not been elucidated before. Primary myelofibrosis is now mainly considered as an advanced stage of BCR-ABL1 negative myeloproliferative neoplasms (MPN), which otherwise include polycythemia vera and essential thrombocythemia. Myelofibrosis is defined by an increased insoluble collagen fiber deposition in the bone marrow2 and harbors chronic inflammation as an important component in disease progression.
Code (0)
등록된 구현이 없습니다.
Similar Papers 제목 키워드 기반
Membrane Trafficking in the Yeast Saccharomyces cerevisiae Model
The yeast Saccharomyces cerevisiae is one of the best characterized eukaryotic models. The secretory pathway was the first trafficking pathway clearly understood mainly thanks to the work done in the laboratory of Randy …
Phosphatidylserine transport in cell life and death
Phosphatidylserine (PS) is a negatively-charged glycerophospholipid found mainly in the plasma membrane (PM) and in the late secretory/endocytic compartments, where it regulates cellular activity and can mediate apoptosi…
Membrane Trafficking of Integral Cell Junction Proteins and its Functional Consequences
Though membrane trafficking of cell junction proteins has been studied extensively for more than two decades, the accumulated knowledge remains fragmentary. The goal of this review is to synthesize published studies on t…
SpecificityPlay-Testing REMind: Evaluating an Educational Robot-Mediated Role-Play Game
This paper presents REMind, an innovative educational robot-mediated role-play game designed to support anti-bullying bystander intervention among children. REMind invites players to observe a bullying scenario enacted b…
SpecMER: Fast Protein Generation with K-mer Guided Speculative Decoding
Autoregressive models have transformed protein engineering by enabling the generation of novel protein sequences beyond those found in nature. However, their sequential inference introduces significant latency, limiting …