Predicting Cardiovascular Risk Factors from Retinal Fundus Photographs using Deep Learning
Traditionally, medical discoveries are made by observing associations and then designing experiments to test these hypotheses. However, observing and quantifying associations in images can be difficult because of the wide variety of features, patterns, colors, values, shapes in real data. In this paper, we use deep learning, a machine learning technique that learns its own features, to discover new knowledge from retinal fundus images. Using models trained on data from 284,335 patients, and validated on two independent datasets of 12,026 and 999 patients, we predict cardiovascular risk factors not previously thought to be present or quantifiable in retinal images, such as such as age (within 3.26 years), gender (0.97 AUC), smoking status (0.71 AUC), HbA1c (within 1.39%), systolic blood pressure (within 11.23mmHg) as well as major adverse cardiac events (0.70 AUC). We further show that our models used distinct aspects of the anatomy to generate each prediction, such as the optic disc or blood vessels, opening avenues of further research.
Code (0)
등록된 구현이 없습니다.
Tasks
AnatomySimilar Papers 제목 키워드 기반
Prediction of Cardiovascular Risk Factors from Retinal Fundus Images using CNNs
Early detection of cardiovascular disease risk factors is essential to alter the course of the disease. Previous studies showed that deep learning can successfully be used to detect such risk factors from retinal images.…
Integrating Deep Learning with Fundus and Optical Coherence Tomography for Cardiovascular Disease Prediction
Early identification of patients at risk of cardiovascular diseases (CVD) is crucial for effective preventive care, reducing healthcare burden, and improving patients' quality of life. This study demonstrates the potenti…
Binary ClassificationDisease PredictionSpecificityArtificial Intelligence in Assessing Cardiovascular Diseases and Risk Factors via Retinal Fundus Images: A Review of the Last Decade
Background: Cardiovascular diseases (CVDs) are the leading cause of death globally. The use of artificial intelligence (AI) methods - in particular, deep learning (DL) - has been on the rise lately for the analysis of di…
PrognosisReplacing the Framingham-based equation for prediction of cardiovascular disease risk and adverse outcome by using artificial intelligence and retinal imaging
Purpose: To create and evaluate the accuracy of an artificial intelligence Deep learning platform (ORAiCLE) capable of using only retinal fundus images to predict both an individuals overall 5 year cardiovascular risk (C…
Camera Adaptation for Fundus-Image-Based CVD Risk Estimation
Recent studies have validated the association between cardiovascular disease (CVD) risk and retinal fundus images. Combining deep learning (DL) and portable fundus cameras will enable CVD risk estimation in various scena…