Prediction of Cross-Fitness for Adaptive Evolution to Different Environmental Conditions: Consequence of Phenotypic Dimensional Reduction
How adaptive evolution to one environmental stress improves or suppresses adaptation to another is an important problem in evolutionary biology. For instance, in microbiology, the evolution of bacteria to be resistant to different antibiotics is a critical issue that has been investigated as cross-resistance. In fact, recent experiments on bacteria have suggested that the cross-resistance of their evolution to various stressful environments can be predicted by the changes to their transcriptome upon application of stress. However, there are no studies so far that explain a possible theoretical relationship between cross-resistance and changes in the transcriptome, which causes high-dimensional changes to cell phenotype. Here, we show that a correlation exists between fitness change in stress tolerance evolution and response to the environment, using a cellular model with a high-dimensional phenotype and establishing the relationship theoretically. The present results allow for the prediction of evolution from transcriptome information in response to different stresses before evolution. The relevance of this to microbiological evolution experiments is discussed.
Code (0)
등록된 구현이 없습니다.
Similar Papers 제목 키워드 기반
Adaptive evolution of hybrid bacteria by horizontal gene transfer
Horizontal gene transfer is an important factor in bacterial evolution that can act across species boundaries. Yet, we know little about rate and genomic targets of cross-lineage gene transfer, and about its effects on t…
Getting higher on rugged landscapes: Inversion mutations open access to fitter adaptive peaks in NK fitness landscapes
Molecular evolution is often conceptualised as adaptive walks on rugged fitness landscapes, driven by mutations and constrained by incremental fitness selection. It is well known that epistasis shapes the ruggedness of t…
Complexity of evolutionary equilibria in static fitness landscapes
A fitness landscape is a genetic space -- with two genotypes adjacent if they differ in a single locus -- and a fitness function. Evolutionary dynamics produce a flow on this landscape from lower fitness to higher; reach…
Analysis of adaptive walks on NK fitness landscapes with different interaction schemes
Fitness landscapes are genotype to fitness mappings commonly used in evolutionary biology and computer science which are closely related to spin glass models. In this paper, we study the NK model for fitness landscapes w…
Reducing the Computational Cost in Multi-objective Evolutionary Algorithms by Filtering Worthless Individuals
The large number of exact fitness function evaluations makes evolutionary algorithms to have computational cost. In some real-world problems, reducing number of these evaluations is much more valuable even by increasing …
Evolutionary Algorithms