Rebuildable biochronometer: inferences and hypothesis on eukaryotic timing system
The biochronometers used to keep time in eukaryotes include short-period biochronometer (SPB) and long-period biochronometer (LPB). Because the circadian clock reflects the biological time rhythm of a day, it is considered as SPB. Telomere shortening, which reflects the decreasing of telomere DNA length of chromosomes with the increase of cell division times, can be used to time the lifespan of organisms, so it is regarded as LPB. It is confirmed that SPB and LPB exist in most eukaryotes, and it is speculated that SPB and LPB are closely related. In this paper, based on existing studies, it is speculated that SPB and LPB of most eukaryotes can be co-attenuated with cell division in the process of aging. Due to the attenuated phenomenon of key components in the biochronometers during the growth and development of organisms, the biochronometers attenuate with the aging. Based on existing research results, it is preliminarily determined that the biochronometers can be rebuilt in the co-attenuated process. When the key components of biochronometers are reversed and increased in the organism, it can lead to the reversal of biochronometers, which further leads to the phenomenon of biological rejuvenation and makes the organism younger. In addition, the rebuilding of biochronometers can also lead to the acceleration of biochronometers and the shortening of the original timing time of biochronometers, thus shortening the life span of organisms. The rebuilding of biochronometers includes the reversal of biochronometers, the truncation of biochronometers timing and Uncoordinated co-attenuation of biochronometer and so on. The reversal of the biochronometers, which leads to rejuvenation, can give us a whole new understanding of life expectancy to be different from anti-aging.
Code (0)
등록된 구현이 없습니다.
Tasks
RhythmSimilar Papers 제목 키워드 기반
Cell-to-cell variability and robustness in S-phase duration from genome replication kinetics
Genome replication, a key process for a cell, relies on stochastic initiation by replication origins, causing a variability of replication timing from cell to cell. While stochastic models of eukaryotic replication are w…
Genome hybridization: A universal way for the origin and diversification of organelles as well as the origin and speciation of eukaryotes
The origin of organelles (mitochondrion, chloroplast and nucleus) remains enigmatic. The endosymbiotic hypothesis that chloroplasts, mitochondria and nuclei descend from the endosymbiotic cyanobacterium, bacterium and ar…
Inferences and Modal Vocabulary
Deduction is the one of the major forms of inferences and commonly used in formal logic. This kind of inference has the feature of monotonicity, which can be problematic. There are different types of inferences that are …
Formal LogicRescaling of spatio-temporal sensing in eukaryotic chemotaxis
Eukaryotic cells respond to a chemoattractant gradient by forming intracellular gradients of signaling molecules that reflect the extracellular chemical gradient - an ability called directional sensing. Quantitative expe…
Human Goal Recognition as Bayesian Inference: Investigating the Impact of Actions, Timing, and Goal Solvability
Goal recognition is a fundamental cognitive process that enables individuals to infer intentions based on available cues. Current goal recognition algorithms often take only observed actions as input, but here we use a B…
Bayesian InferenceSokoban