Sensitivity of metabolic networks: perturbing metabolite concentrations
Sensitivity studies the network response to perturbations. We consider local perturbations of the concentrations of metabolites at an equilibrium. We investigate the responses in the network, both of the metabolite concentrations and of the reaction fluxes. Our approach is purely qualitative, rather than quantitative. In fact, our analysis is based, solely, on the stoichiometry of the reaction network and we do not require any quantitative information on the reaction rates. Instead, the description is done only in algebraic terms, and the only data required is the network structure. Biological applications include metabolic control and network reconstruction.
Code (0)
등록된 구현이 없습니다.
Tasks
SensitivitySimilar Papers 제목 키워드 기반
Enzyme economy and metabolic control
The metabolic state of a cell, comprising fluxes, metabolite concentrations and enzyme levels, is shaped by a compromise between metabolic benefit and enzyme cost. This hypothesis and its consequences can be studied by c…
Sign-sensitivity of metabolic networks: which structures determine the sign of the responses
Perturbations are ubiquitous in metabolism. A central tool to understand and control their influence on metabolic networks is sensitivity analysis, which investigates how the network responds to external perturbations. W…
SensitivityFlux cost functions and optimal metabolic states
The metabolic fluxes in cells follow physical, biochemical, and economic principles. Some flux balance analysis (FBA) methods trade flux benefit against flux cost. However, if flux cost functions are linear and meant to …
Blood-based metabolic signatures in Alzheimer's disease
Introduction: Identification of blood-based metabolic changes might provide early and easy-to-obtain biomarkers. Methods: We included 127 AD patients and 121 controls with CSF-biomarker-confirmed diagnosis (cut-off tau…
Physics-Informed Sylvester Normalizing Flows for Bayesian Inference in Magnetic Resonance Spectroscopy
Magnetic resonance spectroscopy (MRS) is a non-invasive technique to measure the metabolic composition of tissues, offering valuable insights into neurological disorders, tumor detection, and other metabolic dysfunctions…
Bayesian InferenceDecoder