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Spontaneous Activity in the Visual Cortex is Organized by Visual Streams

Large-scale functional networks have been extensively studied using resting state functional magnetic resonance imaging. However, the pattern, organization, and function of fine-scale network activity remain largely unknown. Here we characterized the spontaneously emerging visual cortical activity by applying independent component analysis to resting state fMRI signals exclusively within the visual cortex. In this sub-system scale, we observed about 50 spatially independent components that were reproducible within and across subjects, and analyzed their spatial patterns and temporal relationships to reveal the intrinsic parcellation and organization of the visual cortex. We found that the visual cortical parcels were aligned with the steepest gradient of cortical myelination, and organized into functional modules segregated along the dorsal/ventral pathways and foveal/peripheral early visual areas. In contrast, cortical retinotopy, folding, and cytoarchitecture impose limited constraints to the organization of resting state activity. From these findings, we conclude that spontaneous activity patterns in the visual cortex are primarily organized by visual streams, likely reflecting feedback network interactions.

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