Statistical thermodynamics of the binding energy super-landscape in the adaptive immune system
The humoral adaptive immune system, from the physical perspective, can be regarded as a self-organized antibody binding energy landscape. In biological terms, the system organizes its repertoire of antigen binding molecules so as to maintain its molecular integrity. In this article I reason that the super-landscape created by the fusion of binding energy landscapes can be described by the distribution of interaction energies and deformation parameters of thermodynamic potentials in the system. The deformation parameters characterize the network of interactions in the system and the asymmetry of generalized logistic distributions obtained in immunoassays while probing the system. Overall, a statistical thermodynamics approach can provide a deeper theoretical insight both into the dynamical self-organization of the adaptive immune system and into the interpretation of experimental results.
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