Three-dimensional cell culture model for hepatocytes opens a new avenue of real world research on liver
3-demensional (3D) culture model is a valuable in vitro tool to study liver biology, metabolism, organogenesis, tissue morphology, drug discovery and cell-based assays. Compelling evidence suggests that cells cultured in 3D model exhibit superior liver-specific functions over the conventional 2-dimentional (2D) culture in evaluating hepatobiliary drug disposition and drug-induced hepatotoxicity due to the in vivo-like physiological condition recapitulated by 3D model technologies. We will review the attributes of 3D culture model in acquiring relevant liver phenotypes and functionalities, discuss the critical niche factors found to modulate hepatocytes and highlight recent advancements on 3D cell culture technologies to achieve next-level in vitro tool for preclinical study.
Code (0)
등록된 구현이 없습니다.
Tasks
Cultural Vocal Bursts Intensity PredictionDrug DiscoverySimilar Papers 제목 키워드 기반
Quantification of Nematic Cell Polarity in Three-dimensional Tissues
How epithelial cells coordinate their polarity to form functional tissues is an open question in cell biology. Here, we characterize a unique type of polarity found in liver tissue, nematic cell polarity, which is differ…
Open-Ended Question AnsweringUnderstanding Hepatitis B Virus Infection through Hepatocyte Proliferation and Capsid Recycling
Proliferation of uninfected as well as infected hepatocytes and recycling of DNA-containing capsids are two major mechanisms playing significant roles in the clearance of hepatitis B virus (HBV) infection. In this study,…
Histological insight into the hepatic tissue of the Nile monitor (Varanus niloticus)
The liver of reptiles is considered an important study model for the interaction between environment and hepatic tissue. Little is known about the histology of the liver of reptiles. The aim of the current study was to e…
Inheritance of intracellular viral RNA in a multiscale model of hepatitis C infection
Multiscale mathematical models of hepatitis C infection have been instrumental in our understanding of direct acting antivirals. These models include the mechanisms driving intracellular viral production and explicitly m…
Glucose availability but not changes in pancreatic hormones sensitizes hepatic AMPK activity during nutritional transition in rodents
The cellular energy sensor AMP-activated protein kinase (AMPK) is a metabolic regulator that mediates adaptation to nutritional variations in order to maintain a proper energy balance in cells. We show here that suckling…