A Fluid-Structure Interaction Model of the Zebrafish Aortic Valve
The zebrafish is a valuable model organism for studying cardiac development and diseases due to its many shared aspects of genetics and anatomy with humans and ease of experimental manipulations. Computational fluid-structure interaction (FSI) simulations are an efficient and highly controllable means to study the function of cardiac valves in development and diseases. Due to their small scales, little is known about the mechanical properties of zebrafish cardiac valves, limiting existing computational studies of zebrafish valves and their interaction with blood. To circumvent these limitations, we took a largely first-principles approach called design-based elasticity that allows us to derive valve geometry, fiber orientation and material properties. In FSI simulations of an adult zebrafish aortic valve, these models produce realistic flow rates when driven by physiological pressures and demonstrate the spatiotemporal dynamics of valvular mechanical properties. These models can be used for future studies of zebrafish cardiac hemodynamics, development, and disease.
Code (0)
등록된 구현이 없습니다.
Tasks
AnatomySimilar Papers 제목 키워드 기반
Image-based immersed boundary model of the aortic root
Each year, approximately 300,000 heart valve repair or replacement procedures are performed worldwide, including approximately 70,000 aortic valve replacement surgeries in the United States alone. This paper describes pr…
A Design-Based Model of the Aortic Valve for Fluid-Structure Interaction
This paper presents a new method for modeling the mechanics of the aortic valve, and simulates its interaction with blood. As much as possible, the model construction is based on first principles, but such that the model…
Controlled Comparison of Simulated Hemodynamics across Tricuspid and Bicuspid Aortic Valves
Bicuspid aortic valve is the most common congenital heart defect, affecting 1-2% of the global population. Patients with bicuspid valves frequently develop dilation and aneurysms of the ascending aorta. Both hemodynamic …
Simulation-Based Design of Bicuspidization of the Aortic Valve
Objective: Severe congenital aortic valve pathology in the growing patient remains a challenging clinical scenario. Bicuspidization of the diseased aortic valve has proven to be a promising repair technique with acceptab…
Shape Deformation Networks for Automated Aortic Valve Finite Element Meshing from 3D CT Images
Accurate geometric modeling of the aortic valve from 3D CT images is essential for biomechanical analysis and patient-specific simulations to assess valve health or make a preoperative plan. However, it remains challengi…