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A Hodge-FAST Framework for High-Resolution Dynamic Functional Connectivity Analysis of Higher Order Interactions in EEG Signals

2025-02-01 · Om Roy, Yashar Moshfeghi, Jason Smith, Agustin Ibanez, Mario A. Parra, Keith M. Smith

We introduce a novel framework that integrates Hodge decomposition with Filtered Average Short-Term (FAST) functional connectivity to analyze dynamic functional connectivity (DFC) in EEG signals. This method leverages graph-based topology and simplicial analysis to explore transient connectivity patterns at multiple scales, addressing noise, sparsity, and computational efficiency. The temporal EEG data are first sparsified by keeping only the most globally important connections, instantaneous connectivity at these connections is then filtered by global long-term stable correlations. This tensor is then decomposed into three orthogonal components to study signal flows over higher-order structures such as triangle and loop structures. Our analysis of Alzheimer-related MCI patients show significant temporal differences related to higher-order interactions that a pairwise analysis on its own does not implicate. This allows us for the first time to capture higher-dimensional interactions at high temporal resolution in noisy EEG signal recordings.

📄 PDF Abstract BibTeX arXiv:2502.00249

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Computational EfficiencyEEGFunctional Connectivity

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