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Automated Body Composition Analysis Using DAFS Express on 2D MRI Slices at L3 Vertebral Level

Body composition analysis is vital in assessing health conditions such as obesity, sarcopenia, and metabolic syndromes. MRI provides detailed images of skeletal muscle (SKM), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT), but their manual segmentation is labor-intensive and limits clinical applicability. This study validates an automated tool for MRI-based 2D body composition analysis- (Data Analysis Facilitation Suite (DAFS) Express), comparing its automated measurements with expert manual segmentations using UK Biobank data. A cohort of 399 participants from the UK Biobank dataset was selected, yielding 423 single L3 slices for analysis. DAFS Express performed automated segmentations of SKM, VAT, and SAT, which were then manually corrected by expert raters for validation. Evaluation metrics included Jaccard coefficients, Dice scores, Intraclass Correlation Coefficients (ICCs), and Bland-Altman Plots to assess segmentation agreement and reliability. High agreements were observed between automated and manual segmentations with mean Jaccard scores: SKM 99.03%, VAT 95.25%, and SAT 99.57%; and mean Dice scores: SKM 99.51%, VAT 97.41%, and SAT 99.78%. Cross-sectional area comparisons showed consistent measurements with automated methods closely matching manual measurements for SKM and SAT, and slightly higher values for VAT (SKM: Auto 132.51 cm^2, Manual 132.36 cm^2; VAT: Auto 137.07 cm^2, Manual 134.46 cm^2; SAT: Auto 203.39 cm^2, Manual 202.85 cm^2). ICCs confirmed strong reliability (SKM: 0.998, VAT: 0.994, SAT: 0.994). Bland-Altman plots revealed minimal biases, and boxplots illustrated distribution similarities across SKM, VAT, and SAT areas. On average DAFS Express took 18 seconds per DICOM. This underscores its potential to streamline image analysis processes in research and clinical settings, enhancing diagnostic accuracy and efficiency.

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