Brain Network Dynamics and Multiscale Modelling of Neurodegenerative Disorders: A Review
It is essential to understand the complex structure of the human brain to develop new treatment approaches for neurodegenerative disorders (NDDs). This review paper comprehensively discusses the challenges associated with modelling the complex brain networks and dynamic processes involved in NDDs, particularly Alzheimer's disease (AD), Parkinson's disease (PD), and cortical spreading depression (CSD). We investigate how the brain's biological processes and associated multiphysics interact and how this influences the structure and functionality of the brain. We review the literature on brain network models and dynamic processes, highlighting the need for sophisticated mathematical and statistical modelling techniques. Specifically, we go through large-scale brain network models relevant to AD and PD, highlighting the pathological mechanisms and potential therapeutic strategies investigated in the literature. Additionally, we investigate the propagation of CSD in the brain and its implications for neurological disorders. Furthermore, we discuss how data-driven approaches and artificial neural networks refine and validate models related to NDDs. Overall, this review underscores the significance of coupled multiscale models in deciphering disease mechanisms, offering potential avenues for therapeutic development and advancing our understanding of pathological brain dynamics.
Code (0)
등록된 구현이 없습니다.
Similar Papers 제목 키워드 기반
Nonlocal Models in the Analysis of Brain Neurodegenerative Protein Dynamics with Application to Alzheimer's Disease
It is well known that today nearly one in six of the world's population has to deal with neurodegenerative disorders. While a number of medical devices have been developed for the detection, prevention, and treatments of…
Statistical Opportunities in Neuroimaging
Neuroimaging has profoundly enhanced our understanding of the human brain by characterizing its structure, function, and connectivity through modalities like MRI, fMRI, EEG, and PET. These technologies have enabled major…
Bayesian Approaches for Revealing Complex Neural Network Dynamics in Parkinson's Disease
Parkinson's disease (PD) belongs to the class of neurodegenerative disorders that affect the central nervous system. It is usually defined as the gradual loss of dopaminergic neurons in the substantia nigra pars compacta…
Bayesian InferenceEEG-ReMinD: Enhancing Neurodegenerative EEG Decoding through Self-Supervised State Reconstruction-Primed Riemannian Dynamics
The development of EEG decoding algorithms confronts challenges such as data sparsity, subject variability, and the need for precise annotations, all of which are vital for advancing brain-computer interfaces and enhanci…
EEGEeg DecodingDimensional Neuroimaging Endophenotypes: Neurobiological Representations of Disease Heterogeneity Through Machine Learning
Machine learning has been increasingly used to obtain individualized neuroimaging signatures for disease diagnosis, prognosis, and response to treatment in neuropsychiatric and neurodegenerative disorders. Therefore, it …
Prognosis