Did circoviruses intermediate the recombination between bat and pangolin coronaviruses, yielding SARS-CoV-2?
Since the first reports of a coronavirus (CoV) disease 2019 (COVID-19) caused by severe acute respiratory syndrome virus (SARS-CoV-2) in Wuhan, Hubei province, China, scientists are working around the clock to find sound answers to the issue of its origin. While the number of scientific articles on SARS-CoV-2 is increasing, there are still many gaps as to its origin. All studies failed to find a coronavirus in other animals that is more similar to human SARS-COV2 than the bat virus, considered to be the primary reservoir. In this paper we address a new hypothesis, based on a possible recombination between a DNA and SARS-CoV viruses, to explain the rise of SRAS-CoV-2. By comparing SARS-CoV-2 and related CoVs with circoviruses (CVs), we found strong sequence similarity of the genomic region at the 3-end of Bat-CoV ORF1a and the origin of replication (Ori) of porcine CV type 2 (PCV2), as well as similar RNA secondary structures of the region encompassing the cleavage site of CoV S gene with the PCV2 Ori. This constitutes a primary evidence that supports a possible recombination, which occurrence might explain the origin of SARS-CoV-2.
Code (0)
등록된 구현이 없습니다.
Tasks
ArticlesSimilar Papers 제목 키워드 기반
Analysis of pangolin metagenomic datasets reveals significant contamination, raising concerns for pangolin CoV host attribution
Metagenomic datasets from pangolin tissue specimens have previously yielded SARS-related coronaviruses which show high homology in their receptor binding domain to SARS-CoV-2, suggesting a potential zoonotic source for t…
Further analysis of metagenomic datasets containing GD and GX pangolin CoVs indicates widespread contamination, undermining pangolin host attribution
The only animals other than bats reported to have been infected with SARS-CoV-2-related coronaviruses (SARS2r-CoVs) prior to the COVID-19 pandemic are pangolins. In early 2020 multiple papers reported the identification …
In-silico nucleotide and protein analyses of S-gene region in selected zoonotic coronaviruses reveal conserved domains and evolutionary emergence with trajectory course of viral entry from SARS-CoV2 genomic data
The recent zoonotic coronavirus virus outbreak of a novel type [COVID 19] has necessitated the adequate understanding of the evolutionary pathway of zoonotic viruses which adversely affects human populations for therapeu…
ManagementEvolving ribonucleocapsid assembly/packaging signals in the genomes of the human and animal coronaviruses: targeting, transmission and evolution
A world-wide COVID-19 pandemic intensified strongly the studies of molecular mechanisms related to the coronaviruses. The origin of coronaviruses and the risks of human-to-human, animal-to-human, and human-to-animal tran…
Evolution of viral pathogens follows a linear order
Although lessons have been learned from previous severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) outbreaks, the rapid evolution of the viruses means that future outbreaks of a much la…