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Effort-free Automated Skeletal Abnormality Detection of Rat Fetuses on Whole-body Micro-CT Scans

2021-06-03 · Akihiro Fukuda, Changhee Han, Kazumi Hakamada

Machine Learning-based fast and quantitative automated screening plays a key role in analyzing human bones on Computed Tomography (CT) scans. However, despite the requirement in drug safety assessment, such research is rare on animal fetus micro-CT scans due to its laborious data collection and annotation. Therefore, we propose various bone feature engineering techniques to thoroughly automate the skeletal localization/labeling/abnormality detection of rat fetuses on whole-body micro-CT scans with minimum effort. Despite limited training data of 49 fetuses, in skeletal labeling and abnormality detection, we achieve accuracy of 0.900 and 0.810, respectively.

📄 PDF Abstract BibTeX arXiv:2106.01830

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Tasks

Anomaly DetectionBIG-bench Machine LearningComputed Tomography (CT)Feature Engineering

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