Exploring the underlying mechanisms of Xenopus laevis embryonic cell cycle
Cell cycle is an indispensable process in the proliferation and development. Despite significant efforts, global quantification and physical understanding are still challenging. In this study, we explored the mechanisms of Xenopus laevis embryonic cell cycle by quantifying the underlying landscape and flux. We uncovered the irregular Mexican hat landscape of the Xenopus laevis embryonic cell cycle with several local basins and barriers on the oscillation path. The local basins characterize the different phases of Xenopus laevis embryonic cell cycle and the local barriers represent the checkpoints. The checkpoint mechanism of cell cycle is revealed by the landscape basins and barriers. While landscape shape determines the stabilities of the states on the oscillation path, the curl flux force determines the stability of the cell cycle flow. Replication is fundamental for biology of living. From our quantitative study here, we see that replication can not proceed without energy input. In fact, the curl flux originated from energy or nutrition supply determines the speed of the cell cycle and guarantees the progression. Speed of cell cycle is a hallmark of cancer. Through landscape and flux analysis, one can identify the key elements for controlling the speed. This can help to design effective strategy for drug discovery against cancer.
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Drug DiscoveryNutritionSimilar Papers 제목 키워드 기반
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