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Fixation times on directed graphs

Computing the rate of evolution in spatially structured populations is difficult. A key quantity is the fixation time of a single mutant with relative reproduction rate $r$ which invades a population of residents. We say that the fixation time is "fast" if it is at most a polynomial function in terms of the population size $N$. Here we study fixation times of advantageous mutants ($r>1$) and neutral mutants ($r=1$) on directed graphs, which are those graphs that have at least some one-way connections. We obtain three main results. First, we prove that for any directed graph the fixation time is fast, provided that $r$ is sufficiently large. Second, we construct an efficient algorithm that gives an upper bound for the fixation time for any graph and any $r\ge 1$. Third, we identify a broad class of directed graphs with fast fixation times for any $r\ge 1$. This class includes previously studied amplifiers of selection, such as Superstars and Metafunnels. We also show that on some graphs the fixation time is not a monotonically declining function of $r$; in particular, neutral fixation can occur faster than fixation for small selective advantages.

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