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Improving Phenotype Prediction using Long-Range Spatio-Temporal Dynamics of Functional Connectivity

The study of functional brain connectivity (FC) is important for understanding the underlying mechanisms of many psychiatric disorders. Many recent analyses adopt graph convolutional networks, to study non-linear interactions between functionally-correlated states. However, although patterns of brain activation are known to be hierarchically organised in both space and time, many methods have failed to extract powerful spatio-temporal features. To overcome those challenges, and improve understanding of long-range functional dynamics, we translate an approach, from the domain of skeleton-based action recognition, designed to model interactions across space and time. We evaluate this approach using the Human Connectome Project (HCP) dataset on sex classification and fluid intelligence prediction. To account for subject topographic variability of functional organisation, we modelled functional connectomes using multi-resolution dual-regressed (subject-specific) ICA nodes. Results show a prediction accuracy of 94.4% for sex classification (an increase of 6.2% compared to other methods), and an improvement of correlation with fluid intelligence of 0.325 vs 0.144, relative to a baseline model that encodes space and time separately. Results suggest that explicit encoding of spatio-temporal dynamics of brain functional activity may improve the precision with which behavioural and cognitive phenotypes may be predicted in the future.

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