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Network-Based Detection of Autism Spectrum Disorder Using Sustainable and Non-invasive Salivary Biomarkers

2025-09-19 · Janayna M. Fernandes, Robinson Sabino-Silva, Murillo G. Carneiro arxiv

Autism Spectrum Disorder (ASD) lacks reliable biological markers, delaying early diagnosis. Using 159 salivary samples analyzed by ATR-FTIR spectroscopy, we developed GANet, a genetic algorithm-based network optimization framework leveraging PageRank and Degree for importance-based feature characterization. GANet systematically optimizes network structure to extract meaningful patterns from high-dimensional spectral data. It achieved superior performance compared to linear discriminant analysis, support vector machines, and deep learning models, reaching 0.78 accuracy, 0.61 sensitivity, 0.90 specificity, and a 0.74 harmonic mean. These results demonstrate GANet's potential as a robust, bio-inspired, non-invasive tool for precise ASD detection and broader spectral-based health applications.

📄 PDF Abstract BibTeX arXiv:2509.16126

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