Synergy Test for Antibacterial Activity: Towards the Research for a Consensus between the Fractional Inhibitory Concentration (Checkboard Method) and the Increase in Fold Area (Disc Diffusion Method)
Antibiotic resistance is a topical problem for both humans and animals and has been the subject of special monitoring for two decades. Several recent studies, including ours, have shown that this phenomenon is accentuated by the transfer of certain genetic elements and cross resistance acquisition, the latter or both resulting from the misuse of these antimicrobial drugs. A more careful use of antimicrobials, the search for new antibacterial compounds (including probiotics and phages) are the most recommended alternatives to overcome this situation. However, tests for modulations of antimicrobial activity can also play a major role. The main goal of synergy studies is to assess whether substances with antibacterial properties can improve the effectiveness of existing antimicrobials or give them a second life against resistant germs. Moreover, recent studies have demonstrated the ability of silver nanoparticles and extracts of certain plants to boost the effectiveness of certain antibiotics. such as ampicillin, benzylpenicillin, cefazolin, ciprofloxacin, nitrofurantoin, and kanamycin. Yet, from these studies we found that there was a serious problem with the interpretation of the results when using the disk method with determination of the increase in fold area. Indeed, the use of this method firstly requires the determination of the diameter of inhibition of the antibiotic alone; follow by the determination of the combination of antibiotic + modulating substance (MS) or extract.....
Code (0)
등록된 구현이 없습니다.
Similar Papers 제목 키워드 기반
Antibacterial and antibiofilm activities of a traditional herbal formula against respiratory infection causing bacteria
The plants, Althaea officinalis, Tilia cordata and Psidium guaja have been used traditionally to treat respiratory infection symptoms. Flowers of A. officinalis and leaves of T. cordata and P. guaja have been used to tre…
In Vitro Antibacterial activity of hexane, Chloroform and methanolic extracts of different parts of Acronychia pedunculata grown in Sri Lanka
This study accessed the antibacterial potential in vitro of hexane, chloroform and methanol extracts made from leaves, stem bark, flowers, seeds or roots of Sri Lankan grown Acronychia pedunculata plant against two Gram …
Antibacterial and antifungal activity of various extracts of Bacopa monnieri
Bacopa monnieri was also known as Brahmi. Theses plant has been considered as medicinal plants in Ayurvedic systems for centuries. This present study was carried out to evaluate the antibacterial and antifungal propertie…
ManagementGreen synthesis of silver nanoparticles using Curcuma longa flower extract and antibacterial activity
Silver nanoparticles (AgNP's) possess inherent biological potentials that have obliged an alternative, eco-friendly, sustainable approach to "Green Synthesis." In the present study, we synthesized Green Silver Nanopartic…
X-Ray Diffraction (XRD)Discovery of novel antimicrobial peptides with notable antibacterial potency by a LLM-based foundation model
Large language models (LLMs) have shown remarkable advancements in chemistry and biomedical research, acting as versatile foundation models for various tasks. We introduce AMP-Designer, an LLM-based approach for swiftly …
Knowledge Distillationscientific discovery