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Two-Stage Resampling for Convolutional Neural Network Training in the Imbalanced Colorectal Cancer Image Classification

Data imbalance remains one of the open challenges in the contemporary machine learning. It is especially prevalent in case of medical data, such as histopathological images. Traditional data-level approaches for dealing with data imbalance are ill-suited for image data: oversampling methods such as SMOTE and its derivatives lead to creation of unrealistic synthetic observations, whereas undersampling reduces the amount of available data, critical for successful training of convolutional neural networks. To alleviate the problems associated with over- and undersampling we propose a novel two-stage resampling methodology, in which we initially use the oversampling techniques in the image space to leverage a large amount of data for training of a convolutional neural network, and afterwards apply undersampling in the feature space to fine-tune the last layers of the network. Experiments conducted on a colorectal cancer image dataset indicate the usefulness of the proposed approach.

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