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Deepfake histological images for enhancing digital pathology

An optical microscopic examination of thinly cut stained tissue on glass slides prepared from a FFPE tissue blocks is the gold standard for tissue diagnostics. In addition, the diagnostic abilities and expertise of any pathologist is dependent on their direct experience with common as well as rarer variant morphologies. Recently, deep learning approaches have been used to successfully show a high level of accuracy for such tasks. However, obtaining expert-level annotated images is an expensive and time-consuming task and artificially synthesized histological images can prove greatly beneficial. Here, we present an approach to not only generate histological images that reproduce the diagnostic morphologic features of common disease but also provide a user ability to generate new and rare morphologies. Our approach involves developing a generative adversarial network model that synthesizes pathology images constrained by class labels. We investigated the ability of this framework in synthesizing realistic prostate and colon tissue images and assessed the utility of these images in augmenting diagnostic ability of machine learning methods as well as their usability by a panel of experienced anatomic pathologists. Synthetic data generated by our framework performed similar to real data in training a deep learning model for diagnosis. Pathologists were not able to distinguish between real and synthetic images and showed a similar level of inter-observer agreement for prostate cancer grading. We extended the approach to significantly more complex images from colon biopsies and showed that the complex microenvironment in such tissues can also be reproduced. Finally, we present the ability for a user to generate deepfake histological images via a simple markup of sematic labels.

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